重庆大学附属江津医院医学检验科副主任，副主任技师、副研究员、硕士生导师
联系方式：tangbin118@cqu.edu.cn
教育经历：
2007.09-2012.06， 中国人民解放军第三军医大学，医学检验系，博士
2000.09-2004.06， 中国人民解放军第一军医大学，医学检验系，学士
工作经历：
2023.04-至今， 重庆大学附属江津医院，副主任技师，副研究员
2019.05-2023.03，重庆医科大学附属第三医院，副研究员
2017.06-2019.05，火箭军峨眉疗养院检验科主任，副主任技师
2016.06-2017.06，火箭军峨眉疗养院检验科主任，主治医师
2012.06-2016.06，成都军区峨眉疗养院检验科，主治医师
2004.06-2007.09，成都军区峨眉疗养院检验科，医师
学术任职：
重庆市免疫学会理事
重庆市免疫学会感染免疫专业委员会（第二届）常务委员
重庆市微生物学会临床微生物专委会委员
重庆市医学会消化病学专委会青年委员会委员
iLABMED杂志青年编委
研究方向：
1、具核梭杆菌与结直肠癌的作用机制研究，以及肿瘤药物递送体系研究；
2、病原微生物与智能检验。
招生资格：硕士研究生（临床医学、生物与医药专业学位）
招生专业：临床医学（临床检验诊断学）、生物医药（专业学位）
成果：1.文章2.项目3.获奖
1.文章
1.Bin Tang#,XiaoxueLu#,YananTong#,Yuyang Feng, Yilan Mao, Guodong Dun, Jing Li, Qiaolin Xu,Jie Tang, Tao Zhang, Ling Deng, Xiaoyi He, Yuanzhi Lan, Huaxing Luo, Linghai Zeng, Yuanyuan Xiang,Qian Li*,Dongzhu Zeng* and Xuhu Mao*. MicroRNA-31 induced by Fusobacterium nucleatum infection promotes colorectal cancer tumorigenesis.iScience. 2023, 26(5):106770.(Q1,IF=6.5)
2.Jie Tang#, Xiaoxue Lu#, Tao Zhang, Yuyang Feng, Qiaolin Xu, Jing Li,Yuanzhi Lan, Huaxing Luo, Linghai Zeng, Yuanyuan Xiang, Yan Zhang, Qian Li , Xuhu Mao,Bin Tang*, Dongzhu Zeng*. Shiga toxin 2 A-subunit induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells. Heliyon, 2023, 9(9): e20012.(Q2,IF=4.0)
3.XiaoxueLu#,Qiaolin Xu#,TongYanan,Zhang Zhujun,Dun Guodong,Feng Yuyang,Tang Jie,Han Dan,MaoYilan,Deng Ling,He Xiaoyi,Li Qian,Xiang Yang,Wang FengChao,Dongzhu Zeng*,Bin Tang*,and XuhuMao*. Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis. Cell Reports. 2022, 40(3):111127.(Q1,IF=9.99)
4.QiaolinXu,Xiaoxue Lu,Jing Li,Yuyang Feng,Jie Tang,Tao Zhang,Yilan Mao,Yuanzhi Lan,Huaxing Luo,Linghai Zeng,Yuanyuan Xiang,Lv Hu,Yan Zhang,Qian Li,Ling Deng,Xiaoyi He,Bin Tang*,Xuhu Mao*,Dongzhu Zeng*. Fusobacterium nucleatum induces excess methyltransferaselike 3-mediated microRNA-4717-3p maturation to promote colorectal cancer cell proliferation. Cancer science. 2022, DOI: 10.1111/cas.15536.(Q2,IF=6.5)
5.Jie Tang, Guodong Dun, Jing Li, Qiaolin Xu, Tao Zhang, Yuanzhi Lan,Linghai Zeng,Huaxing Luo*, Yuanyuan Xiang*,Bin Tang*, Dongzhu Zeng*. Isolation of Fusobacterium nucleatum from human feces using immunomagnetic separation coupled with fastidious anaerobe agar. J Appl Microbiol. 2022 Dec 16;lxac058. (Q2,IF=4.1)
6.Bin Tang#, Qian Li#, Xiu-Hua Zhao#, Wang Hai-Guang, Li Na, Fang Yao, Wang Kun, Jia Yin-Ping, Zhu Pan, Gu Jiang, Li Jing-xin, Jiao Yong-jun, Tong Wen-de, Wang Marissa, Zou Quan-ming, Feng-cai Zhu* & Xu-hu Mao*, Shiga toxins induce autophagic cell death in intestinal epithelial cells via the endoplasmic reticulum stress pathway, Autophagy, 2015, 11(2): 344-354.(Q1,IF=13.3)
7.Qian Li, Fang Yao, Zhu Pan, Ren Chun-yan, Chen Hai, Gu Jiang, Yin-ping Jia, Kun Wang, Wen-de Tong, Wei-jun Zhang, Jing Pan, Dong-shui Lu,Bin Tang*and Xu-hu Mao*, Burkholderia pseudomallei inhibits autophagy to benefit its intracelluar survival in lung epithelial cells through miRNAs-mediated ATG10 suppression, Autophagy, 2015,11(8): 1293-1307.(Q1,IF=13.3)
8.Bin Tang#, Na Li#, Gu Jiang, Zhuang Yuan, Li Qian, Wang Hai-Guang, Yao Fang, Bo Yu, Jin-Yu Zhang, Qing-Hua Xie, Li Chen, Xue-Jun Jiang, Bin Xiao, Quan-Min Zou* and Xu-HuMao*, Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori, Autophagy, 2012, 8(7):1045-57.(Q1,IF=13.3)
9.Pan Zhu#, Jun Xue, Zhu-jun Zhang, Yin-ping Jia, Ya-nan Tong, Dan Han, Qian Li, Yang Xiang, Xu-hu Mao*,Bin Tang*, Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway, Cell Death and Disease, 2017,8:3207.(Q1,IF=9.0)
10.Zhao Yang,Changlong Zhou,Hui Shi,Nan Zhang,Bin Tang*,Na Ji*.Heme Induces BECN1/ATG5-Mediated Autophagic Cell Death via ER Stress in Neurons. Neurotoxicity Research, 2020, 38(4):1037-1048.(Q2,IF=3.7)
11.Bin Tang#, Kun Wang#, Jia Yin-ping, Zhu Pan, Fang Yao, Zhu-jun Zhang, Xuhu Mao, Qian Li*, Dong-Zhu Zeng*, Fusobacterium nucleatum-Induced Impairment of Autophagic Flux Enhances the Expression of Proinflammatory Cytokines via ROS in Caco-2 Cells, PLoS ONE, 2016,11(11): e0165701.(Q2,IF=3.7)
12.Yin-ping Jia#, Kun Wang, Zhu-jun Zhang, Ya-nan Tong, Dan Han, Chun-yu Hu, Qian Li, Yang Xiang, Xu-hu Mao*,Bin Tang*, TLR2/TLR4 activation induces Tregs and suppresses intestinal inflammation caused by Fusobacterium nucleatum in vivo, PLoS ONE, 2017,12(10): e0186179.(Q2,IF=3.7)
13.Na Li#,Bin Tang#, Yin-ping Jia, Pan Zhu, Yuan Zhuang, Yao Fang, Qian Li, Kun Wang, Wei-jun Zhang, Gang Guo, Tong-jian Wang, You-jun Feng, Bin Qiao*, Xu-hu Mao*and Quan-ming Zou*, Helicobacter pylori CagA Protein Negatively Regulates Autophagy and Promotes Inflammatory Response via c-Met-PI3K/Akt-mTOR Signaling Pathway, Front. Cell. Infect. Microbiol, 2017, 7:417.(Q1,IF=5.7)
14.Yan Shi#，Bin Tang#，Yu Pei-Wu，Tang Bo，Hao Ying-Xue，Lei Xiao，Luo Hua-Xing，Dong-Zhu Zeng*，Autophagy Protects against Oxaliplatin-Induced Cell Death via ER Stress and ROS in Caco-2 Cells，PLOS ONE，2012,7（11）：1-6.(Q2,IF=3.7)
15.Bin Tang#, Bin Xiao#, Liu Zhen, Li Na, Zhu En-Dong, Li Bo-Sheng, Quan-MinZou* and Xu-HuMao*, Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation, FEBS Lett, 2010, 584:1481-6.(Q2,IF=3.5)
2.项目
1.国家自然科学基金青年项目，项目名称：EGFR介导幽门螺杆菌空泡毒素诱导胃上皮细胞自噬型死亡的机制研究，项目主持。
2.全军医学科技青年培育项目，项目名称：EHEC O157:H7志贺毒素引起溶血性尿毒综合症的致病机制的研究，项目主持。
3.重庆市自然科学基金面上项目, 项目名称：TRIB3介导的线粒体自噬在EHEC O157:H7志贺毒素所致肠上皮细胞自噬性死亡中的作用及机制研究，项目主持。
4.重庆大学附属江津医院科研领军项目，项目名称：具核梭杆菌促进Septin9-YY1复合体形成在结直肠癌转移中的作用机制研究，项目主持。
5.重庆大学附属江津医院人才引进启动经费项目，项目名称：具核梭杆菌凝集素Fap2促进GLUT1 O-糖基化在结直肠癌转移中的作用机制研究，项目主持。
3.立功获奖
1.2020年，获得重庆市渝北区“临空创新人才”
2.2018年，获得全军检验医学专委会青年人才奖和优秀技师奖
3. 2017年，获得火箭军医药卫生成果奖一等奖（排名第一）
4. 2017年，获得个人三等功一次
5. 2016年，获得享受军队优秀人才津贴
6. 2015年，获得成都军区“学习成才先进个人”
7.2014年，获得“重庆市优秀博士论文”
8.2013年，获得“全军优秀博士论文提名”
