教授，Joseph S. Pagano Award获得者
Email：huifeng2022@cqu.edu.cn。
学习经历
2008/09-2011/07中国科学院武汉病毒研究所博士
2004/09-2007/06华中农业大学硕士
2000/09-2004/06河北农业大学学士
科研经历
2022/05-至今重庆大学医学院，教授
2020/04-2022/03河北省沧州中西医结合医院，实验室主任
2014/10-2019/09美国北卡罗来纳大学教堂山分校，博士后
2011/08-2014/09中国科学院水生生物研究所，博士后
研究方向、教学课程
研究方向：
病毒致病及逃逸机理
研究生教学：主讲博士研究生课程《论文写作与科研绘图》、《科研伦理与学术诚信》；参与硕士研究生课程《分子生物学技术》、《分子与细胞》、《发育与遗传》、《疾病与防治》、《医学前沿进展》理论与实践教学。
成果（1.文章2.项目3.获奖）
文章
1.Zhao J-Y, Yuan X-K, Luo R-Z, Wang L-X, Gu W, Yamane D*,Feng H*. Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction.Frontiers in Immunology. 2023,14:1107239.
Sun L#,Feng H#,Misumi I, Shirasaki T, Hensley L,González-López O,Chou WC, Ting JP, Cullen JM, Cowley DO, Whitmire JK, Lemon SM*. Viral protease cleavage of MAVS in genetically-modified mice with hepatitis A virus infection.Journal ofHepatology.2023, 78(2):271-280.
2.Shirasaki T#,Feng H#, Duyvesteyn HME, Fusco WG, McKnight KL, Xie L, Boyce M, Kumar S, Barouch-Bentov R, González-López O, McNamara R, Wang L, Hertel-Wulff A, Chen X, Einav S, Duncan JA, Kapustina M, Fry EE, Stuart DI, Lemon SM.Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.PLoS Pathogens. 2022,18(8):e1010543.
3.Feng H,Zhang YB, Gui JF, Lemon SM*, Yamane D*. Interferon regulatory factor 1 (IRF1) and antipathogen innate immune responses.PLoS Pathogens. 2021,17(1):e1009220.
4.Feng H,Sander AL,Moreira-Soto A, Yamane D,Lemon SM*.Hepatovirus 3ABC proteases and evolution of mitochondrial antiviral signaling protein (MAVS).Journal ofHepatology.2019. 71(1):25-34.
5.Yamane D*,Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK, Lemon SM*.Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.NatureMicrobiology.2019,4(7):1096-1104.
6.Feng H, Lenarcic EM, Yamane D,Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM*.NLRX1promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.NatureImmunology.2017,18(12):1299-1309.
7.Feng H#, Zhang QM#, Zhang YB*, Li Z, Zhang J, Xiong YW, Wu M, Gui JF. Zebrafish IRF1, IRF3 and IRF7 differentially regulate IFNΦ1 and IFNΦ3 expression through assembly of homo- or heteroprotein complexes.Journal ofImmunology. 2016,197(5):1893-904.
8.Hirai-Yuki A, Hensley L, McGivern DR, González-López O, Das A,Feng H, Sun L, Wilson JE, Hu F, Feng Z, Lovell W, Misumi I, Ting JP, Montgomery S, Cullen J, Whitmire JK, Lemon SM*.MAVS-dependent host species range and pathogenicity of human hepatitis A virus.Science.2016,353(6307):1541-1545.
9.Guo H#, König R#, Deng M, Riess M, Mo J, Zhang L, Petrucelli A, Yoh SM, Barefoot B, Samo M, Sempowski GD, Zhang A, Colberg-Poley AM,Feng H, Lemon SM, Liu Y, Zhang Y, Wen H, Zhang Z, Damania B, Tsao LC, Wang Q, Su L, Duncan JA, Chanda SK*, Ting JP*.NLRX1sequesters STING tonegativelyregulate theinterferonresponse,therebyfacilitating thereplication of HIV-1 and DNAviruses.Cell Host&Microbe. 2016,19(4):515-528.
10.Feng H, Zhang YB*, Zhang QM, Li Z, Zhang QY, Gui JF*. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling.Journal ofImmunology. 2015,194(3):1225-38.
11.Drexler JF*, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brünink S, Rasche A, Seggewiβ N,Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C; Hepatovirus Ecology Consortium.Evolutionary origins of hepatitis A virus in small mammals.Proc Natl Acad Sci U S A. 2015,112(49):15190-5.
12.Guo M,Feng H, Zhang J, Wang W, Wang Y, Li Y, Gao C, Chen H, Feng Y, He ZG*.Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system.Genome Research.2009,19(7):1301-8.
承担课题
国家重点研发计划（课题） |
2023.12-2026.11 |
主持 |
国家自然科学基金面上项目 |
2024.01-2027.12 |
主持 |
重庆市自然科学面上项目 |
2023.09-2026.08 |
主持 |
重庆市留学人员回国创业创新支持计划 |
2024.01-2026.12 |
主持 |
云南省重大专项 |
2023.06-2026.05 |
参与 |
美国NIH R01-AI131685科研项目 |
2017.03-2022.02 |
参与 |
美国NIH R01- AI03083科研项目 |
2012.09-2022.08 |
参与 |
美国NIH U19-AI109965科研项目 |
2014.04-2019.03 |
参与 |
窗体顶端
科研奖励
2017年度Joseph S. Pagano Award
窗体底端
窗体顶端
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