石磊 副教授

2001-2005 上海交通大学 学士学位
2005-2010 中国科学院生物物理研究所 博士学位

细胞生物学

研究描述：研究肿瘤形成和迁移的分子机制，及其与机体免疫系统的互作关系。

细胞生物学
免疫学

重庆市生物化学与分子生物学学会

主持国家自然基金青年项目1项，教育部博士点新教师基金1项，中央高校科研业务经费面上项目1项。
发表论文：
Shi L, Liu Y, Li M, Luo Z. Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity. FEBS J. 2021 May 27. doi: 10.1111/febs.16034.
Huang R, Zhou L, Chi Y, Wu H, Shi L*. LncRNA profile study reveals a seven-lncRNA signature predicts the prognosis of patients with colorectal cancer. Biomark Res. 2020 Feb 28;8:8. (*Corresponding author)
Qian Y, Shi L*, Luo Z*. Long Non-coding RNAs in Cancer: Implications for Diagnosis, Prognosis, and Therapy. Front Med (Lausanne). 2020 Nov 30;7:612393. (*Corresponding author)
Zhao Z, Zhang C, Zhou L, Dong P*, Shi L*. Neurotoxicities associated with immune checkpoint inhibitor therapy. Curr Neuropharmacol. 2020 Dec 30. (*Corresponding author)
Shi, L.*, Yu, L., Zou, F., Hu, H., Liu, K., & Lin, Z.* (2017). Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmospheric plasma-activated medium. Peerj, 5:e3751. *Corresponding author
Shi L*, Zhang W, Zou F, Mei L, Wu G, Teng Y*. KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma. BMC Cancer. 2016 Oct 21;16(1):815. *Corresponding author
Shi L, Wu L, Wang S, Fan Z. Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation. Cell Death and Differentiation 2009 Dec;16(12):1694-706.
Zhang H, Zhong C, Shi L, Guo Y, Fan Z. Granulysin induces cathepsin B release of lysosomes of target tumor cells to target mitochondria through processing of Bid. Journal of Immunology 2009; 182(11):6993-7000.
D Hu, S Liu, L Shi, L Wu, C Li, Z Fan. Cleavage of survivin by Granzyme M triggers degradation of the survivin-XIAP complex to free caspase activity leading to cytolysis of target tumor cells. Journal of Biological Chemistry 2010 Jun 11;285(24):18326-35.
Guo Y*, Chen J*, Shi L, Fan Z. Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. Journal of Immunology 2010; 185(9):5348-59. (*equal contribution)
Wang S, Xia P, Shi L, Fan Z. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. Cell Death and Differentiation 2011; 19(4): p.605-15.
Shi, GQ, QY Yu, L Shi, Z Zhang*. Molecular cloning and characterization of peroxiredoxin 4 involved in protection against oxidative stress in the silkworm Bombyx mori. Insect Mol Biol 2012; 21: 581-92

邮箱：shil@cqu.edu.cn