李葆生,男,1985年4月出生,2016年9月加入重庆大学化学化工学院,任特聘研究员、博士生导师。2013年博士毕业于兰州大学(导师:曹小平 教授;涂永强 ), 2012年至2013年在香港中文大学做研究助理(导师: Hak-Fun Chow 教授),2013年至2016年在新加坡南洋理工大学从事博士后研究(导师: Robin Chi 教授),2017年入选“青年人才托举工程”人才计划。目前主持“青年人才托举工程”人才项目经费、国家自然科学基金面上项目、重庆大学科研启动基金。迄今以在国际主流期刊Nature Communications、JACS、Chemical Science等杂志上发表学术论文20余篇。主要从事活性化合物的合成,有机合成方法学的发展,化学生物学等方面的研究。
电话:15826063819
邮箱:libs@cqu.edu.cn;libaoshengqq@163.com
地址:重庆大学虎溪校区化学化工学院711室
欢迎对有机合成化学、化学生物学感兴趣的同学加入本课题组的硕士及博士研究生!
研究兴趣
1.有机合成方法学的发展
2. 药物分子、活性化合物的合成及生物活性研究
3. 小分子靶向药物的合成及其在肿瘤诊疗和转化医学等领域中的应用
教育背景
2008-2013 博士 兰州大学 化学化工学院 有机合成 (导师:涂永强 ;曹小平 教授)
2004-2008 学士 贵州大学 化学化工学院 制药工程
工作经历
2016-至今 特聘研究员 重庆大学 化学化工学院
2013-2016 博后 新加坡南洋理工大学 化生系 (导师: Robin Chi 教授)
2012-2013 研究助理 香港中文大学, 化学院 (导师: Hak-Fun Chow 教授)
获人才计划及主持基金项目情况
1.中国科协”青年人才托举”项目基金(所有化学学科2017年共8人入选)
2.国家自然科学基金面上项目
3.重庆大学“青年百人计划”基金
以第一作者发表论文
7. Carbene-catalyzed reductive coupling of nitrobenzyl bromides and ketones via single-electron-transfer process.Bao-Sheng Li; Yuhuang, Wang; Rupert S. J. Proctor; Yuexia Zhang; Richard D. Webster; Song Yang; Baoan Song; Yonggui Robin Chi*,Nature Communications.2016,7,in press.
6.Carbene-catalyzed desymmetrization of 1,3-diols: access to optically enriched tertiary alkyl chlorides.Bao-Sheng Li; Yuhuang, Wang; Rupert S. J. Proctor; Zhichao, Jin; Yonggui Robin Chi*,Chem. Commun,2016,52, 8313.
5.Carbon–carbon bond activation of cyclobutenones enabled by the addition of chiral organocatalyst to ketone.Bao-Sheng, Li;Yuhuang Wang,Zhichao Jin,Pengcheng Zheng,Rakesh Ganguly&Yonggui Robin Chi*,Nature Communications.2015,6, 6207.
4.Cycloaddition of cyclobutenone and azomethine imine enabled by chiral isothiourea organic catalysts.Bao-Sheng Li, Yuhuang Wang, Zhichao Jin and Yonggui Robin Chi*,Chemical Science,2015,6, 6008.
3. Direct Synthesis of Spiro- and Fused-Hydrofurans via Tunable Tandem Semipinacol Rearrangement/Oxa-Michael Addition.Bao-Sheng, Li; Wen-Xing, Liu; Fu-Min, Zhang; Shao-hua, Wang; Yong-Qiang, Tu*; Xiao-Ping, Cao*,Chenistry - A European Journal,2013,19, 5246.
2. Copper(I)-catalyzed Intramolecular [2 + 2] Cycloaddition of 1,6-enyne-derived Ketenimine: an Efficient Construction of Strained and Bridged 7-substituted-3- Heterobicyclo[3.1.1]heptan-6-one.Bao-Sheng Li; Bin-Miao, Yang; Shao-Hua, Wang; Yong-Qiang, Zhang; Xiao-Ping, Cao*; Yong-Qiang, Tu*,Chemical. Science.,2012, 3, 1975.Highlighted by Synfacts,2012,8, 0868.
1.One-Pot Construction of Multi-Substituted Spiro-Cycloalkanediones by an Organocatalytic
Asymmetric Epoxidation/Semipinacol Rearrangement.Bao-Sheng, Li; En, Zhang; Qing-Wei, Zhang; Fu-Min, Zhang; Yong-Qiang, Tu*;Xiao-Ping Cao*,Chem–Asian. J.,2011,6, 2269.
以共同作者发表论文
8.Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols. Zhijian Huang, Xuan Huang,Baosheng Li, Chengli Mou, Song Yang, Bao-An Song, and Yonggui Robin Chi.J. Am. Chem. Soc.,2016,138, 7524.
7.N-Heterocyclic Carbene-Catalyzed δ-Carbon LUMO Activation of Unsaturated Aldehydes.. Tingshun Zhu, Chengli Mou,Baosheng Li, Marie Smetankova, Bao-An Song, and Yonggui Robin Chi*,J. Am. Chem. Soc.,2015,137, 5658.
6.Catalytic asymmetric semipinacol rearrangements. Shao-Hua Wang,Bao-Sheng Liand Yong-Qiang Tu,Chem. Commun.,2014,50, 2393.
5.Construction of fused- and spiro-oxa-[n.2.1] skeletons by a tandem epoxide rearrangement/intramolecular [3+2] cycloaddition of cyclopropanes with carbonyls. Lu-Feng Wang, Zi-Fa Shi, Xiao-Ping Cao*,Bao-Sheng Liand Peng An.Chem. Commun.,2014,50, 8061.
4.Catalytic intermolecular carbon electrophile induced semipinacol rearrangement. Qing-Wei Zhang, Xiao-Bo Zhang,Bao-Sheng Li, Kai Xiang, Fu-Min Zhang, Shao-Hua Wang and Yong-Qiang Tu*.Chem. Commun.,2013,49, 1648.
3.Palladium-Catalyzed Cascade Process To Construct 1,2,5-Trisubstituted Pyrroles. Yong-Qiang, Zhang; Dao-Yong, Zhu;Bao-Sheng, Li; Yong-Qiang, Tu*; Yong, Lu; Sho-Hua, Wang.J. Org. Chem.,2012,77, 4167.
2. Total Synthesis of Malyngamides K, L, and 5′′-epi-C and Absolute Configuration of Malyngamide L. Jun-Tao, Zhang; Xian-Liang, Qi; Jie, Chen;Bao-Sheng, Li; You-Bai, Zhou; Xiao-Ping, Cao*.J. Org. Chem.,2011,76, 3946.
1. Regiodivergent Annulation of AlkynylIndoles To Construct Spiro-pseudoindoxyl and Tetrahydro-β-carbolines. Yong-Qiang, Zhang; Dao-Yong, Zhu; Zhi-Wei, Jiao;Bao-Sheng, Li; Fu-Min, Zhang; Yong-Qiang, Tu*,Org. Lett.,2011,13, 3458.